Cook pasta to package directions (al dente) and drain it. Pour into greased 13x9 dish and toss in 2tbs of butter. Set aside.
Melt 1/4 cup of butter over medium heat.
Stir in flour and whisk to combine.
Add milk and heavy cream. Whisk while it thickens a tiny bit.
Whisk in the seasonings and then stir in 1 1/2 cups of the cheddar, 1/2 cup of the mozzarella and the american cheese torn into pieces. Keep stirring until all of the cheese is melted.
Pour cheese sauce over the pasta and stir to combine well. It will seem like there's too much sauce, but there's not, don't worry!
Sprinkle the rest of the cheddar and mozzarella cheese on top. Sprinkle breadcrumbs and oregano on top of that.
Bake for about 30 minutes - it should be bubbly and the cheese should be melted.